Immunity Indexes at the System and Local Levels of Pregnant Women with Mycoplasma Infection

Examination of immunity disorders at the system and local levels in pregnant women with persistent mycoplasma infection has been carried out. The analysis has revealed depression of circulating in blood CD3+ and CD4+, increase of CD16+ and CD19+, decrease of activated CD25+ and ready to adaptation CD95+ lymphocytes. Studies of the concentration of cytokines at the local level (cervical mucus) in pregnant women with mycoplasma infection showed a significant increase in concentrations of both proinflammatory (TNF-ά, IL-6) and antiinflammatory (IL-4 in 4.5 times) cytokines compared with controls group (P <0.05 and P <0.01), which confirms the presence of an inflammatory process not only at the system level, but locally. That means that pregnant women with mycoplasma infection in comparison with healthy pregnant women were indicated with violations of the regulation system of cytokines in peripheral blood and locally in the cervical mucus. It is characterized by increased TH-1 cell response to the increasing fusion of proinflammatory cytokines (IL-1, IL-6, IFN-γ, TNF-ά), and pointed to the imbalance of their products, which may be a factor in this pregnancy complication. NAGIMA MAMEDALIYEVA, SAULE ISSENOVA, LUDMILA DZOZ